Harada Lab | Sophia University
List of Original Papers
50.
Shinji Harada,* Atsushi Nishida*
Lanthanide Metal-Catalyzed Enantioselective Diels-Alder Reactions of Acid-Labile Siloxydienes: Taming Sensitive Substrates through Catalyst Design
Synlett accepted for publication
49.
Shigeru Arai,* Shinji Harada, Kenzo Yamatsugu
Isatogen and Isatogenol: New Precursors for Facile Preparation of Highly Functionalized Heterocycles
Synlett accepted for publication
48.
Shinji Harada,* Nanami Tsuji, Sora Fukushima, Juntaro Yamamoto, Shigeru Arai, Tetsuhiro Nemoto
Redox-Adaptive Auto-Tandem Catalysis: Ce(III)/Ce(IV) Interconversion-Mediated Integration of Nazarov Cyclization and Oxidative Hydroxylation
ACS Catal. 2025, 15, 14341-14347.
47.
Aurapat Ngamnithiporn, Padon Chuentragool, Supakarn Punnita, Wachirawit Thitseesaeng, Teesuda Sirichai, Shinji Harada, Tetsuhiro Nemoto, Poonsakdi Ploypradith, Somsak Ruchirawat
Synthesis of Isoquinoline N-Oxides via Hypervalent Iodine-Mediated Oxidative Cyclization of Ketoximes with Alkenes
J. Org. Chem. 2025, 90, 8145-8151.
46.
Nanaka Ishihara, Ryu Fukuoka, Shinji Harada, Kenzo Yamatsugu, Shigeru Arai
Regio- and Stereoselective [3 + 2] cycloaddition of Isatogens with functionalized alkenes and its application to the synthesis of Halichrome A
Tetrahedron Lett. 2025, 167, 155626.
45.
Tetsuhiro Nemoto, Shingo Harada, Takahito Kuribara, Shinji Harada
Recent advances in the synthesis of 3,4-fused tricyclic indoles
Org. Biomol. Chem. 2025, 23, 4808-4827.
44.
Tanawat Phumjan, Tomohiro Yazawa, Shinji Harada,* Tetsuhiro Nemoto
Bridged-Type Selective Intramolecular Nitrone–Alkene Cycloaddition: Computational Chemistry-Inspired Regioselectivity Control
Org. Lett. 2025, 27, 1549-1554.
43.
Shinji Harada,* Shihori Sekino, Marisa Inaba, Ayumi Okita, Tetsuhiro Nemoto, Shigeru Arai, Hitomi Ohmagari, Miki Hasegawa, Atsushi Nishida
Synthesizing Chiral Hydrocarbazoles with a Tetrasubstituted Carbon Using Holmium-Catalyzed Enantioselective [4+2] Cycloaddition: Mechanistic Insights from Luminescence and DFT Studies
J. Org. Chem. 2024, 89, 8305-8310.
42.
Nanaka Ishihara, Shinji Harada, Masaya Nakajima, Shigeru Arai
Isatogenols as Precursors for the Synthesis of Fully Substituted Indolines through Regio- and Stereoselective [3+2] Cycloaddition Using Various Olefins
Org. Lett. 2024, 26, 2908-2912.
41.
Ryoka Sakai, Nanaka Ishihara, Shinji Harada, Shigeru Arai
B(C6F5)3-catalyzed regio- and stereoselective cyanation of isatogens and their derivatives
Tetrahedron Lett. 2024, 137, 154909.
40.
Shigeru Arai, Koichi Nakazawa, Xiao-Fei Yang, Masaya Nakajima, Shinji Harada, Atsushi Nishida
Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations
Org. Biomol. Chem. 2024, 22, 3606-3610.
39.
Shinji Harada,* Juntaro Yamamoto, Akito Okabe, Shigeru Arai
Photocatalytic Dearomative Intermolecular Seven-Membered Ring Construction of Benzofurans
Asian J. Org. Chem. 2023, e202300467.
38.
Shinji Harada,* Ryotaro Koyama, Ryuya Masuda, Shigeru Arai
Trichloromethylative Olefin Lactonization by Photoredox Catalysis
Eur. J. Org. Chem. 2023, e202300747.
37.
Yasumasa Hara, Teruhisa Manome, Wataru Suehiro, Shinji Harada, Yoshikazu Yamagishi, Akiko Takaya, Yasumitsu Ogra, Masami Ishibashi
Isolation of two new trichorzin PA derivatives, trichorzin PA X and XI, from the terrestrial fungus Trichoderma harzianum IFM 66736
Tetrahedron. Lett. 2023, 121, 154488.
36.
Shinji Harada,* Ryuya Masuda, Takahiro Morikawa, Atsushi Nishida
Trichloromethylative Olefin Cycloamination by Photoredox Catalysis
Eur. J. Org. Chem. 2021, 4531-4535.
35.
Yasumasa Hara, Yuichi, Totsugi, Hiroshi Ichikawa, Shinji Harada, Kazuki Fujii, Firoj Ahmed, Samir K. Sadhu, Midori A. Arai, Masami Ishibashi
Acacienone, a terpenoid-like natural product having an unprecedented C20 framework isolated from Acacia mangiumleaves
J. Nat. Med. 2021, 75, 99-104.
34.
Ruirong Yi, Yoshifumi Ohno, Zheng Tian, Shuhan Guo, Weiwei Chen, Xue Ma, Nan Nwe Win, Qisen Li, Majid Vahed, Kengo Saito, Shingo Nakamoto, Akiko Suganami, Naohisa Isegawa, Keisuke Yoshida, Shinji Harada, Yutaka Tamura, Atsushi Nishida, Hiroshi Shirasawa
CCL113, a novel sulfonamide, induces selective mitotic arrest and apoptosis in HeLa and HepG2 cells
Oncol. Rep. 2020, 44, 2770-2782.
33.
Shinji Harada*
Catalytic Synthesis of Optically Active Polycyclic Heterocyclic Compounds
Yakugaku Zasshi 2020, 140, 1213-1224.
32.
Shinji Harada,* Daiki Matsuda, Takahiro Morikawa, Atsushi Nishida
Direct Synthesis of Enones by Visible-Light-Promoted Oxygenation of Trisubstituted Olefins Using Molecular Oxygen.
Synlett 2020, 31, 1372-1377.
31.
Shinji Harada,* Saki Nakashima, Shihori Sekino, Wakana Oishi, Atsushi Nishida
Optically Active Helical Lanthanide Complexes: Storable Chiral Lewis Acidic Catalysts for Enantioselective Diels-Alder Reaction of Siloxydienes
Chem. Asian J. 2020, 15, 483-486.
30.
Akito Okabe, Shinji Harada,* Takuya Takeda, Atsushi Nishida
One-Pot Synthesis of Cycloocta[b]indole through Formal [5+3] Cycloaddition Using Donor-Acceptor Cyclopropanes
Eur. J. Org. Chem. 2019, 3916-3920.
29.
Shinji Harada and Atsushi Nishida
Catalytic and Enantioselective Diels-Alder Reaction of Siloxydienes
Asian J. Org. Chem. 2019, 8, 732-745.
28.
Takuya Takeda, Shinji Harada,* Akito Okabe, Atsushi Nishida
Cyclohepta[b]indole Synthesis through [5+2] Cycloaddition: Bifunctional Indium(III)-Catalyzed Stereoselective Construction of 7-Membered Ring Fused Indoles
J. Org. Chem. 2018, 83, 11541-11551.
27.
Haruka Homma, Shinji Harada,* Atsushi Nishida
Enantioselective carbonyl-ene-type cyclization of -ketoester and 2-substituted vinylsilane catalyzed by a chiral Cu-BOX complex
Tetrahedron Lett. 2018, 59, 2755-2758.
26.
Siyuan Wu, Shinji Harada, Takahiro Morikawa, Atsushi Nishida
Total Synthesis of Carbazomycins A and B
Chem. Pharm. Bull. 2018, 66, 178-183.
25.
Siyuan Wu, Shinji Harada, Takahiro Morikawa, Atsushi Nishida
Enantioselective total synthesis of a natural hydrocarbazolone alkaloid, identification of its stereochemistry, and revision of its spectroscopic data
Tetrahedron: Asymmetry 2017, 28, 1083-1088.
24.
Shinji Harada, Saki Nakashima, Wataru Yamada, Takahiro Morikawa, Atsushi Nishida
Catalytic and Enantioselective Diels-Alder Reaction of Silyloxydiene That Incorporates a Pyrrolidine Ring, and Its Application to the Construction of Chiral Tri- and Tetracyclic Skeletons.
Heterocycles 2017, 95, 872-893.
23.
Shinji Harada, Kexin Li, Ryuto Kino, Takuya Takeda, Chia-Hsien Wu, Shiharu Hiraoka, Atsushi Nishida
Construction of Optically Active Isotwistanes and Aminocyclitols Using Chiral Cyclohexadiene as a Common Intermediate
Chem. Pharm. Bull. 2016, 64, 1474-1483.
22.
Takuya Takeda, Shinji Harada,* Atsushi Nishida
Catalytic Asymmetric Nazarov Cyclization of Heteroaryl Vinyl Ketones through a Crystallographically Defined Chiral Dinuclear Nickel Complex
Org. Lett. 2015, 17, 5184-5187.
21.
Takahiro Morikawa, Shinji Harada, Atsushi Nishida
Chiral Holmium Complex-Catalyzed Synthesis of Hydrocarbazole from Siloxyvinylindole and Its Application to the Enantioselective Total Synthesis of (–)-Minovincine
J. Org. Chem. 2015, 80, 8859-8867.
20.
Shinji Harada, Haruka Ishii, Daisuke Shirasaki, Atsushi Nishida
Catalytic and Enantioselective Synthesis of a Key Intermediate of the MCHr1 Antagonist AMG 076
Heterocycles 2015, 90, 967-977.
19.
Keisuke Yoshida, Takahiro Morikawa, Naoto Yokozuka, Shinji Harada, Atsushi Nishida
Stereoselective synthesis of chiral hydrocarbazoles via the catalytic Diels-Alder reaction of siloxyvinylindole and cyclic Z-olefin
Tetrahedron Lett. 2014, 55, 6907-6910.
18.
Shinji Harada, Takahiro Morikawa, Atsushi Nishida
Chiral Holmium Complex-Catalyzed Diels-Alder Reaction of Silyloxyvinylindoles: Stereoselective Synthesis of Hydrocarbazoles
Org. Lett. 2013, 15, 5314-5317.
17.
Shinji Harada, Takahiro Morikawa, Shiharu Hiraoka, Atsushi Nishida
Development of Catalytic and Enantioselective Diels-Alder Reaction of Electron-Rich Dienes Using Chiral Rare-Earth Metal Complex
J. Synth. Org. Chem., Jpn. 2013, 71, 818-829.
16.
Chenghong Huang, Theresa Liang, Shinji Harada, Eunsung Lee, Tobias Ritter
Silver-Mediated Trifluoromethoxylation of Aryl Stannanes and Arylboronic Acids
J. Am. Chem. Soc. 2011, 133, 13308-13310.
15.
Shiharu Hiraoka, Shinji Harada, Atsushi Nishida
Abnormal Ito-Saegusa Oxidation of TIPS Enol Ether Assisted by a Hydroxy Group
Tetrahedron Lett. 2011, 52, 3079-3082.
14.
Shiharu Hiraoka, Shinji Harada, Atsushi Nishida
Catalytic Enantioselective Total Synthesis of (–)-Platyphyllide and Its Structural Revision
J. Org. Chem. 2010, 75, 3871-3874.
13.
Shinji Harada, Nozomi Toudou, Shiharu Hiraoka, Atsushi Nishida
Highly Enantioselective Diels-Alder Reaction of Danishefsky-Type Diene and Electron-deficient Olefins Catalyzed by an Yb(III)/Chiral Bis-urea Complex
Tetrahedron Lett. 2009, 50, 5652-5655.
12.
Keiichi Hara, Shin-ya Tosaki, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga, Masakatsu Shibasaki
Mixed La–Li heterobimetallic complexes for tertiary nitroaldol resolution
Tetrahedron 2009, 65, 5030-5036.
11.
Yukinori Sudo, Daisuke Shirasaki, Shinji Harada, Atsushi Nishida
Highly Enantioselective Diels-Alder Reactions of Danishefsky Type Dienes with Electron-Deficient Alkenes Catalyzed by Yb(III)-BINAMIDE Complexes
J. Am. Chem. Soc. 2008, 130, 12588-12589.
10.
Sean H. Wiedemann, Hidetoshi Noda, Shinji Harada, Shigeki Matsunaga, Masakatsu Shibasaki
Sc3+-Catalyzed Aldol-type Additions of N-Benzoyl-cyclopropanecarboxamides via Iodide-Mediated Ring-Opening: Stereoselective Synthesis of γ-Lactams
Org. Lett. 2008, 10, 1661-1664.
9.
Ryo Takita, Shinji Harada, Takashi Ohshima, Shigeki Matsunaga, Masakatsu Shibasaki
Catalytic Enantioselective Addition of Terminal Alkynes to Aldehydes: Preparation of (S)-(–)-1,3-Diphenyl-2-Propyn-1-ol and (S)-(–)-4-Methyl-1-Phenyl-2-Pentyn-1,4-Diol
Org. Synth. 2008, 85, 118-130.
8.
Shinji Harada, Ryo Takita, Takashi Ohshima, Shigeki Matsunaga, Masakatsu Shibasaki
Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor
Chem. Commun. 2007, 948-950.
7.
Shin-ya Tosaki, Keiichi Hara, Vijay Gnanadesikan, Hiroyuki Morimoto, Shinji Harada, Mari Sugita, Noriyuki Yamagiwa, Shigeki Matsunaga, Masakatsu Shibasaki
Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution
J. Am. Chem. Soc. 2006, 128, 11776-11777.
6.
Hiroyuki Morimoto, Sean H. Wiedemann, Akitake Yamaguchi, Shinji Harada, Zhihua Chen, Shigeki Matsunaga, Masakatsu Shibasaki
Trichloromethyl ketones as synthetically versatile donors: application in direct catalytic Mannich-type reactions and the stereoselective synthesis of azetidines
Angew. Chem. Int. Ed. 2006, 45, 3146-3150.
5.
Shinji Harada, Shinya Handa, Shigeki Matsunaga, Masakatsu Shibasaki
Direct Catalytic Asymmetric Mannich-Type Reactions of N-(2-Hydroxyacetyl)-pyrroles as an Ester-Equivalent Donor
Angew. Chem. Int. Ed. 2005, 44, 4365-4368.
4.
Shigeki Matsunaga, Tomofumi Kinoshita, Shigemitsu Okada, Shinji Harada, Masakatsu Shibasaki
Catalytic Asymmetric 1,4-Addition Reactions Using α,β-Unsaturated N-Acylpyrroles as Highly Reactive Monodentate α,β-Unsaturated Ester Surrogates
J. Am. Chem. Soc. 2004, 126, 7559-7570.
3.
Shigeki Matsunaga, Naoya Kumagai, Shinji Harada, Masakatsu Shibasaki
anti-Selective Direct Catalytic Asymmetric Mannich-type Reaction of Hydroxyketone Providing β-amino Alcohols
J. Am. Chem. Soc. 2003, 125, 4712-4713.
2.
Shinji Harada, Naoya Kumagai, Tomofumi Kinoshita, Shigeki Matsunaga, Masakatsu Shibasaki
Direct Catalytic Asymmetric Michael Reaction of Hydroxyketones: Asymmetric Zn Catalysis with a Et2Zn/linked-BINOL Complex
J. Am. Chem. Soc. 2003, 125, 2582-2590.
1.
Naoya Kumagai, Shigeki Matsunaga, Tomofumi Kinoshita, Shinji Harada, Shigemitsu Okada, Shigeru Sakamoto, Kentaro Yamaguchi, Masakatsu Shibasaki
Direct Catalytic Asymmetric Aldol Reaction of Hydroxyketones: Asymmetric Zn Catalysis with a Et2Zn/linked-BINOL Complex
J. Am. Chem. Soc. 2003, 125, 2169-2178.
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